Life-saving potential in spider venom to halt effects of heart attacks
By Vin Se
"After heart attack, blood flow to the heart is reduced, resulting in lack of oxygen to heart muscle," University of Queensland scientist Nathan Palpant said Australia-based scientists are looking to venom from deadly native spider to actually save lives, by halting harmful effects of heart attacks.
Researchers used venom from a type of funnel-web spider among world's deadliest species in a drug they hope can soon be taken to human trials.
So far the experimental medicine has only been lab-tested.
Venom helped stop body sending a "death signal" after heart attack, which causes cells to die.
"Lack of oxygen causes cell environment to become acidic, which combine to send message for heart cells to die, despite decades of research, no one has been able to develop drug that stops this death signal in heart cells, which is one of the reasons why heart disease continues to be leading cause of death in the world."
The team has successfully used protein from spider venom on beating human heart cells that were exposed to heart-attack stresses.
"The Hi1a protein from spider venom blocks acid-sensing ion channels in the heart, so death message is blocked, cell death is reduced, and we see improved heart cell survival," Palpant stressed.
It is hoped the drug could help not only prevent heart damage and save lives, but improve quality of donated hearts during transplants.
Previous research has indicated funnel-web spider venom may also be useful in curbing damage from strokes.
The University of Queensland said the team was aiming for human clinical trials for both stroke and heart disease "within two to three years".
The most recent research was published in the latest edition of the journal Circulation.
jl212777@gmail.com
WordPress.com
No comments:
Post a Comment