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Volunteers to catch COVID in the name of science,wanted

By Nidz Godino

"This is the immune response we then need to induce with a new vaccine," Oxford University Professor of Vaccinology and the study's chief investigator Helen McShane,said world's first medical trial authorized to deliberately expose participants to coronavirus is seeking more volunteers as it steps up efforts to help develop better vaccines.

The Oxford University trial was launched last April, 3,2021, months after Britain became  first country to approve what are known as challenge trials for humans involving COVID-19.

Its first phase, still ongoing, has focused on finding out how much of  virus is needed to trigger an infection while  second will aim to determine  immune response needed to ward one off.

Researchers are close to establishing  weakest possible virus infection that assures about half of people exposed to it get asymptomatic or mild COVID-19.

They then plan to expose volunteers  all previously naturally infected or vaccinated  to that dose of the virus's original variant to determine what levels of antibodies or immune T-cells are required to prevent  infection.

The trial's findings will help make future vaccine development much quicker and more efficient, the statement said.

Global immunologists have been seeking to pinpoint  immune reaction that  vaccine must produce to shield against  illness, known as  correlate of protection. Once discovered, the need for mass vaccine trials is greatly reduced.

Scientists have used human challenge trials for decades to develop treatments against many infectious diseases, but this is the first known such research into COVID-19.

A drawback is the risk of harm to volunteers contracting the disease but the university is taking precautions.

Participants will need to be healthy and aged 18-30. They will be quarantined for at least 17 days and any who develop symptoms will be given Regeneron's monoclonal antibody treatment Ronapreve.

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